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Muscular Dystrophy
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refers to, not one, but a group of muscle diseases. These diseases have three features in common: they are hereditary; they are progressive; and each causes a characteristic and selective pattern of weakness. Duchenne (DMD) is the most prevalent and severe childhood form of this group of diseases.
Each form of is caused by a defect in a spe ....
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....e extracellular matrix and the internal scaffolding of the muscle cells. Mutations in the Duchenne gene result in dystrophin deficiency, which constitutes the pathogenic basis of DMD. Dystrophin is either absent or severely deficient in a person with DMD. When dystrophin is lost through gene mutation, the muscle falls apart under the tension gen.... |
| Word count: 1991 |
Page count: 8 |
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